Objective To study the period of modern times Chinese medicine treatment of thyroid disease by use cluster analysis.Methods Consult medical works of the modern times, then extract Chinese medicine treatment of thyroid disease from those works, and put the involved herbs into a database by Excel software. Frequency analysis and cluster analysis were applied to analyze the prescription law. Results There were 38 doctors, 50 medical records, 61 formulas selected involving 179 herbs, with medication frequency of 871, in which the medication frequency of Xiakucao, Muli, Zhebeimu, Xuanshen, Danggui,...