Objective To investigate the antibacterial activity of Qiwei Xiaocuo decoction on the pathogenic bacteria of acne. Methods The Qiwei Xiaocuo decoction was prepared. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MICC) of Qiwei Xiaocuo decoction on Staphylococcus aureus, Staphylococcus epidermidis and Propionibacterium acnes were determined by 2-fold dilution method, and then use the Oxford Cup inhibition zone to legally test the antibacterial activity of Qiwei Xiaocuo drinking water against Staphylococcus aureus, Staphylococcus aureus and Propionibacterium a...