期刊论文

Explore the mechanisms of traditional Chinese medicine internal and external treatment on chronic osteomyelitis

中文

中国医师杂志

1008-1372

2010

12

6

765-767

10.3760/cma.j.issn.1008-1372.2010.06.017

湖南中医药管理局资助课题（2008070）；

本校为第一机构

目的 观察中药内服外敷对慢性骨髓炎治疗的作用.方法 建立慢性骨髓炎实验动物模型再清创,随机分为两组(抗生素组为对照组,抗生素加中药组为观察组),分别干预10 d后取窦道口周围组织行病理切片观测新生微血管,用ELISA法检测EVGF的表达.结果 抗生素加中药组的VEGF的表达及窦道口周围血管积分较抗生素组明显升高[(47.48±3.22)μg/ml vs(28.26±2.61)μg/ml,P＜0.01;8.03±1.73 vs 5.17±2.89,P＜0.05].结论 中药内服外敷可以提高VEGF的表达和窦道口周围组织内毛细血管数量,从而促进慢性骨髓炎的愈合.

Objective To observe the effect of iraditional Chinese medicine internal and external treatment on chronic osteomyelitis. Method Chronic osteomyelitis experimental animal models were set up with debridement, then it was random divided into two groups （antibiotics group for the control group, antibiotics and traditional Chinese medicine group for the observation group）. After treatment for 10 days, new capillaries in the tissues surrounding sinus crossings were detected by pathological observation and VEGF expression was determined by ELISA. R...