期刊论文

Effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure

中文

中国医师杂志

1008-1372

2015

3

340-342+346

10.3760/cma.j.issn.1008-1372.2015.03.006

国家自然科学基金资助项目（81373816）； 湖南省研究生科研创新项目（CX2013B327）；

本校为第一机构

目的：探讨益心泰颗粒对慢性心力衰竭（ CHF）兔心肌重构的影响。方法用阿霉素建立CHF家兔模型，将造模成功的家兔分为模型组、益心泰低、中、高剂量组和氯沙坦钾组；另设正常对照组。灌胃4周后观察超声心动图指标、心肌重构指标。结果与模型组比较，各用药组左心室后壁（LVPW）厚度、左心室收缩末期内径（LVIDs）、左心室舒张末期内径（LVIDd）、心脏指数（CI）及左心室重量指数（ LVWI）明显降低，差异有统计学意义（ P ＜0．05， P ＜0．01）；与模型组比较，益心泰中、高剂量组室间隔厚度（IVS）显著降低，差异有统计学意义（ P ＜0．01）。与益心泰低剂量组比较，益心泰中、高剂量组IVS、L...

Objective To explore the effect of Yixintai granule on myocardial remodeling in rabbits with chronic heart failure ( CHF) .Methods The rabbit model of CHF with adriamycin was established. These successful CHF models of rabbits were divided into model group, high,middle, and low dose of Yix-intai groups, losartan potassium group, and normal control group.Echocardiographic indexes and myocardi-al remodeling indexes were measured after 4 weeks of medication.Results Compared to the model group, the left ventricular posterior wall (LVPW), left ventricular internal diameter at end-systole (LVIDs), l...