期刊论文

Effects of Chaihu-Longgu-Muli Decoction on the levels of blood superoxide dismutase and maiondialdehyde in Temporal Lobe Epilepsy patients

中文

中国医师杂志

1008-1372

2018

20

03

357-359,363+357-359,363

10.3760/cma.j.issn.1008-1372.2018.03.010

(81603512):National Natural Science Foundation of China (15C1051):Scientific Research of Hunan Educational Committee (2017A04、2017B01)国家自然科学基金(81603512):Foundation of Brain Hospital of Hunan Province (15C1051):湖南省教育厅科研项目 (2017A04、2017B01):湖南省脑科医院院级课题

本校为第一机构

目的 探讨柴胡加龙骨牡蛎汤(CLMD)对颞叶癫痫患者超氧化物歧化酶(SOD)、丙二醛(MDA)的影响.方法 将65例颞叶癫痫患者,按完全随机表法分成奥卡西平组(32例)、奥卡西平+CLMD组(33例),治疗28 d后,观察两组临床疗效、血清中SOD、MDA变化及不良反应.结果 奥卡西平+ CLMD组临床总有效率为87.8％,显著高于奥卡西平组53.1％,差异有统计学意义(P＜0.05);两组治疗后SOD升高、MDA降低,与治疗前比较差异有统计学意义(P＜0.05或P＜0.01),且奥卡西平+CLMD组较奥卡西平组SOD升高、MDA降低(P＜0.05或P＜0.01);两组不良反应比较差异无统计学意义(P＞0.05).结论 CLMD对颞叶癫痫患者有明确治疗作用,安全性高,其机制...

Objective To investigate the effects of Chaihu-Longgu-Muli Decoction （CLMD） on superoxide dismutase （SOD） and maiondiaidehyde （MDA） in patients with temporal lobe epilepsy （TLE）. Methods 65 patients with TLE were randomly divided into Oxearbazepine group （n = 32 ） and Oxcarbazepine ＋ CLMD group （n = 33）. After 28 d, the curative effect, SOD, MDA changes in serum and side effect were observed between two groups. Results The clinical effective rate in Oxearbazepine ＋ CLMD group was 87.8% , slightly higher than that of the Oxcarbazep...