期刊论文

中文

中国医师杂志

1008-1372

2022

24

3

387-391

10.3760/cma.j.cn431274-20211117-01197

湖南省卫生健康委计划课题（20200427, 20200538）；

本校为第一机构

目的:研究抑制素βB(INHBB)在鼻咽癌和肺腺癌组织中的表达及其与临床病理特征的关系。方法:回顾性收集在湖南省脑科医院(湖南省第二人民医院)经活检病理确诊的39例鼻咽癌组织和16例慢性鼻咽炎组织的石蜡标本，以及经手术切除的30例肺腺癌患者的癌组织和癌旁组织的石蜡标本，采用免疫组织化学SP法检测INHBB在鼻咽癌和肺腺癌组织中的表达，同时分析其与临床病理指标的关系。结果:INHBB在鼻咽癌组织中的表达低于慢性鼻咽炎组织(51.28% vs 81.25%， P＝0.039)，且鼻咽癌患者的INHBB表达与淋巴转移( P＝0.026)和临床分期( P＝0.039)有关；INHBB在肺腺癌组织的表达水平显著高于癌旁组织(86.67% vs ...

Objective:To investigate the expression of inhibin β B (INHBB) in nasopharyngeal carcinoma (NPC) and lung adenocarcinoma (LUAD) and its relationship with clinicopathological features.Methods:Paraffin-embedded tissue specimens of 39 patients with NPC and 16 patients with chronic nasopharyngitis diagnosed by biopsy, and 30 patients with LUAD after surgical resection collected in Brain Hospital of Hunan Province (the Second People′s Hospital of Hunan Province) were analyzed retrospectively. The expression of INHBB in NPC and LUAD was detected by...