期刊论文

Neuroprotective effect of Chuanjin jieyu decoction on chronic stress-induced depression rat model

中文

中国医师杂志

1008-1372

2023

25

12

1794-1799

10.3760/cma.j.cn431274-20230504-00599

湖南省临床医学研究中心(2021SK4022) 湖南省重点研发项目(2020SK2123) 湖南省卫生计生委科研课题(202103090662,202203094023)。

本校为第一机构

目的研究川金解郁汤对慢性不可预知性应激(CUMS)诱导的抑郁大鼠模型的神经保护作用。方法48只成年雄性健康SD大鼠,随机选取12只为对照组,其余大鼠建立CUMS抑郁模型。将建模成功后的大鼠随机分成3组:CUMS组、氟西汀...展开更多 目的研究川金解郁汤对慢性不可预知性应激(CUMS)诱导的抑郁大鼠模型的神经保护作用。方法48只成年雄性健康SD大鼠,随机选取12只为对照组,其余大鼠建立CUMS抑郁模型。将建模成功后的大鼠随机分成3组:CUMS组、氟西汀组和川金解郁汤组;分别给予0.9%氯化钠溶液氟西汀、川金解郁汤干预4周。造模后、干预后通过旷场实验、糖水偏爱实验,测定大鼠抑郁水平;干预后采用实时荧光定量...

Objective To study the neuroprotective effect of Chuanjin Jieyu decoction on a chronic unpredictable stress(CUMS)induced depression rat model.Methods A total of 48 adult male healthy Sprague-Dawley(SD)rats were randomly selected,with 12 rats as the control group,and the...MORE Objective To study the neuroprotective effect of Chuanjin Jieyu decoction on a chronic unpredictable stress(CUMS)induced depression rat model.Methods A total of 48 adult male healthy Sprague-Dawley(SD)rats were randomly selected,with 12 rats as the control group,and the remaining rats were used to establish a CUMS depres...