期刊论文

Song, Zhenyan;Ge, JW

英文

Biomedicine & Pharmacotherapy

0753-3322

2020

123

109664

10.1016/j.biopha.2019.109664

The research is supported by the National Natural Science Foundation of China (Grant No. 81774174 ); the Postdoctoral Research Foundation of China (Grant No. 2019M652784 ); the Natural Science Foundation of Hunan Province (Grant No. 2019JJ50441 ); the Scientific Research Foundation of Hunan Provincial Education Department (Grant No. 18B246 ; No. 18C0400 ) and Hunan Administration of Traditional Chinese Medicine Science Foundation (Grant No. 201825 ). Hunan province traditional Chinese medicine decoction piece standardization and function engineering technology research center open foundation (Grant No, 201806 ). Appendix A

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Atherosclerosis (AS) is one of the leading causes of cardiovascular disease and has a high rate of morbidity and mortality. Traditional Chinese Medicine (TCM) supplied many therapies for AS treatment for centuries. Among these treatments, BuYangHuanWu decoction (BYHWD) is a classic prescription. In this study, we analyzed the mechanisms of BYHWD in the treatment of AS by using a network pharmacology method. Our results revealed the mechanisms of BYHWD in treating AS, which is highly related to inflammation and apoptosis pathways, moreover, the genes including IL1 beta, TGFB1, TNF, IL6, NF kapp...