期刊论文

Tang, F.-Q.

中文

中南大学学报(医学版)

1672-7347

2001

26

4

301-304

10.3321/j.issn:1672-7347.2001.04.004

国家自然科学基金资助项目 （ 39770 933）； 中南大学***基金；

本校为其他机构

目的:探讨中药复方益气解毒颗粒防治鼻咽癌的作用机制.方法:用二亚硝基哌嗪(DNP)诱导大鼠鼻咽癌动物模型,观察益气解毒颗粒对大鼠鼻咽癌变中病理形态改变以及端粒酶和端粒酶RNA表达的影响.定期分批处死大鼠,取鼻咽组织作病理学检测,用PCR-ELISA和Nested RT-PCR法检测大鼠鼻咽组织端粒酶的活性和端粒酶RNA的表达.结果:灌服益气解毒颗粒大鼠鼻咽癌发癌率0(0/5),明显低于盐水对照组80%(4/5)(包括原位癌和浸润癌);其端粒酶活性为0.24±0.11,也明显低于对照组0.93±0.23(P

Objective: Telomerase activation is a common event in malignant transformation, and is associated with tumorigenesis. This has been clarified in nasopharyngeal carcinoma. YIQIJIEDU powder (Chinese traditional medicine) is used to treated the patients with nasopharynegeal carcinoma (NPC) after radio - therapy and patients with precancerous lesion of NPC. We investigated whether YIQIJIEDU powder inhibits the telomersae activity in nasopharyngeal carcinogenesis. Methods: Nasopharyngeal carcinomas in rats were induced by N, N' Dinitrosopiperazine (DNP), and some of them were treated with YIQIJIEDU...