期刊论文

Xie, J.

中文

中南大学学报(医学版)

1672-7347

2009

34

9

874-878

10.3321/j.issn:1672-7347.2009.09.007

湖南省自然科学基金（08JJ3039）~~；

本校为其他机构

目的:研究外周血单个核细胞中Foxp3 mRNA表达水平与同种异体肾移植术后急性排斥反应及慢性移植肾肾病发生的关系.方法:应用实时荧光定量聚合酶链式反应(RT-PCR)的方法检测16例肾移植术后急性排斥患者、8例慢性移植肾肾病患者、8例移植后肾功能正常者、8例尿毒症患者和8例正常人的新鲜外周血单个核细胞中Foxp3 mRNA的表达水平,比较各组的差异及其与急性排斥反应和慢性移植肾肾病发生的关系.结果:急性排斥反应患者外周血中Foxp3 mRNA表达水平低于慢性移植肾肾病患者,差异有统计学意义(P

Objective To investigate the relationship between the level of Foxp3 mRNA in the peripheral blood monocytes （PBMCs） with acute rejection or chronic allograft nephropathy after kidney allotransplantation. Methods Real-time quantitative polymerase chain reaction was used to examine Foxp3 mRNA expression in the PBMCs from 16 patients with acute rejection, 8 patients with chronic allograft nephropathy, 8 patients at stable stage after kidney transplantation, 8 patients of end-stage renal disease, and 8 normal controls. Results The level of Foxp3 ...