期刊论文

Liu, Y.(liuyf@csu.edu.cn)

中文

中南大学学报(自然科学版)

1672-7207

2013

44

3

907-913

20090162120013:高等学校博士学科点专项科研基金 12JJ9046:湖南省自然科学(株洲)联合基金资助项目 2012zzts053:中央高校基本科研业务费专项中南大学项目 AL120004:创新训练项目 11C0951:湖南省教育厅项目

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以O-羧甲基壳聚糖(OCMC)为载体、戊二醛(GA)为交联剂,采用乳化交联法制备包覆盐酸头孢吡肟(CD)的药物缓释微球。以OCMC质量分数、CD与OCMC质量比(m(CD)/m(OCMC))、交联剂用量(V(GA)/m(OCMC))及油相乳化剂Span80质量分数为自变量,以载药量和包封率为因变量,采用星点设计-效应面法优化制备工艺,并对优化后的工艺进行验证。所得最优制备条件如下:OCMC质量分数为2.7%,m(CD)/m(OCMC)为0.665,交联剂用量V(GA)/m(OCMC)为8mL/g,Span80质量分数为4%;在最优工艺条件下制备的微球外观圆整,平均粒径为7μm,粒度跨距为1.52,载药量和包封率分别为(21.4±0.5)%和(42.3±0.7)%,缓释时间达到10d以上;星点设计-效应...

O-carboxymethylchitosan (OCMC) microspheres containing an antibiotic drug cefepime dihydrochloride (CD) were prepared by emulsion crosslinking using glutaraldehyde (GA). The central composite design-response surface methodology was used to optimize process variables and the optimized formulation was validated. The OCMC concentration in the aqueous phase, mass ratio of CD to OCMC (m(CD)/m(OCMC)), the dosage of crosslinker (V(GA)/m(OCMC)) and the Span80 concentration in the organic phase were listed as independent variables and the dependent variables were drug-loading and encapsulation efficien...