期刊论文

Liu, Yanfei

中文

中南大学学报(自然科学版)

1672-7207

2014

45

7

2171-2175

湖南省自然科学基金资助项目（13JJ3099）； 湖南省自然科学-株洲联合基金资助项目（12JJ9046）； 中南大学中央高校基本科研业务费专项资金资助项目（2013zzts176）；

本校为其他机构

以新型聚合物聚碳酸亚丙酯马来酸酯(PPCM)为载体,采用Oil/Water单乳液溶剂挥发法制备药物非那雄胺(finasteride)的缓释微球,并研究聚合物PPCM与药物finasteride的质量比对微球特性的影响。研究结果表明:所得PPCM微球外观圆整,平均粒径约为2 μm。随着非那雄胺比例的增加,微球的载药量提高,而药物的包封率则明显降低。在m(PPCM):m(finasteride)为5:1的条件下,获得较高的载药量和包封率,分别为14.78%和66.17%。在pH 7.4的磷酸盐缓冲溶液中,载药微球的体外释放时间达42 d,药物累积释放量为(92.59±2.62)%。微球的释药特性符合Higuchi方程Q_t=3.11+15.07 t~(1/2)。PPCM适用于长效缓释药物传递系统。...

The novel polymer poly(propylene carbonate maleate) (PPCM) was used as drug carriers, PPCM microspheres loaded with drug finasteride were prepared by oil-in-water emulsion solvent evaporation method, and the effects of mass ratios of polymer to drug on the properties of PPCM microspheres were examined. The results show that PPCM microspheres have spherical surface, and the mean diameter of microspheres is approximately 2 μm. With the increase of finasteride proportion, the drug loading increases, while the encapsulation efficiency decreases obviously. Greater drug loading and encapsulation ...