期刊论文

Liu, L.

中文

中南大学学报(医学版)

1672-7347

2018

43

3

246-252

10.11817/j.issn.1672-7347.2018.03.003

国家自然科学基金

本校为第一机构

目的:探讨Notch信号通路与兔深II度烧伤模型创面血管相关因子表达的关系。方法:120只新西兰大白兔,随机分为阻滞剂组、模型组、对照组。其中阻滞剂组于造模前1 d及造成深II度烫伤后连续14 d按2 mg/kg注射γ-分泌酶阻滞剂(gamma-secretase inhibitor,GSI),每天1次;模型组同期注射生理盐水,每天1次;对照组不予造模,余同模型组。每组分别于第3,7,14,21,28天随机抽取8只处死,采用免疫组织化学法检测血管内皮生长因子(vascular endothelial growth factor,VEGF)、血管内皮细胞生长因子受体2(vascular endothelial growth factor receptor 2,VEGFR-2)、基质金属蛋白酶2(matrix metalloprotein 2,MMP-2...

Objective: To investigate the relationship between the Notch signaling pathway and expression of vascular relevant factors in rabbit deep II degree burn model. Methods: A total of 120 New Zealand white rabbits were randomly divided into a block group, a model group, and a control group. The block group was injected 2 mg/kg γ-secretase inhibitor (GSI) once a day at 1 d before the model establishment, and 1-14 d after the deep II degree burns model establishment. The model group were injected physiological saline at the same time. The control gr...