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Radiomics in predicting tumor molecular marker P63 for non-small cell lung cancer

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成果类型:
期刊论文
论文标题(英文):
影像组学在预测非小细胞肺癌分子标志物P63中的应用价值
作者:
Gu, Qianbiao;Feng, Zhichao;Hu, Xiaoli;Ma, Mengtian;Mustafa Jumbe, Mwajuma;...
通讯作者:
Rong, P.
作者机构:
[Gu, Qianbiao] Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013
[Liu, Peng; Gu, Qianbiao] Department of Radiology, People's Hospital of Hunan Province, First Affiiated Hospital, Hunan Normal University, Changsha 410002, China
[Feng, Zhichao; Ma, Mengtian; Rong, Pengfei; Yan, Haixiong] Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China
[Hu, Xiaoli] First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
[Mustafa Jumbe, Mwajuma] Department of Radiology, Muhimbili National Hospital, Dar es Salaam 65000, Tanzania
通讯机构:
Department of Radiology, Third Xiangya Hospital, Central South University, Changsha, China
语种:
中文
关键词:
非小细胞肺癌;计算机体层摄影;影像组学
关键词(英文):
P63
期刊:
中南大学学报(医学版)
ISSN:
1672-7347
年:
2019
卷:
44
期:
9
页码:
1055-1062
基金类别:
supported by the National Natural Science Foundation of China (81771827,81471715).
机构署名:
本校为其他机构
院系归属:
第一中医临床学院
摘要:
目的:建立基于非小细胞肺癌(non-small cell lung cancer,NSCLC)肿瘤CT图像的影像组学模型,预测NSCLC分子标志物P63的表达状态.方法:回顾性分析2014年1月至2018年3月接受CT扫描的245例NSCLC患者.患者均经组织病理学检查确诊,并在CT检查后2周内进行P63表达状态检测.通过MaZda软件提取CT平扫图像的影像组学特征,并且定义肿瘤CT图像的主观影像征象.使用Lasso-logistic回归模型进行特征筛选并分别建立影像组学模型、主观影像征象模型及融合诊断模型.通过受试者操作特征(receiver operator characteristic,ROC)曲线评估每个模型的预测性能,并采用Delong检验进行比较.结果:在245例患者中,P63阳性96例,...
摘要(英文):
Objective: To establish a radiomics signature based on CT images of non-small cell lung cancer (NSCLC) to predict the expression of molecular marker P63. Methods: A total of 245 NSCLC patients who underwent CT scans were retrospectively included. All patients were confirmed by histopathological examinations and P63 expression were examined within 2 weeks after CT examination. Radiomics features were extracted by MaZda software and subjective image features were defined from original non-enhanced CT images. The Lasso-logistic regression model wa...

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