期刊论文

Imaging changes in brain microstructural in long-term abstinent from methamphetamine-dependence

Liu, J.

中文

中南大学学报(医学版)

1672-7347

2019

44

5

491-500

10.11817/j.issn.1672-7347.2019.05.004

2016YFC0800908:国家科技重点研发计划 81671671:国家自然科学基金

本校为其他机构

目的:探究长期戒断甲基苯丙胺依赖者大脑微观结构的影像改变机制。方法:对26例长期戒断依赖者(戒断时间长于14个月)和26例对照组进行认知执行功能测试和扩散张量成像(diffusion-tensor imaging,DTI)检查,利用基于体素的分析方法对两组的部分各向异性(fractional anisotropy,FA)和平均扩散率(mean diffusivity, MD)进行比较,获得组间参数差异脑区,将长期戒断甲基苯丙胺组异常脑区参数值与测试结果行Spearman相关分析。结果:长期戒断甲基苯丙胺组和对照组的认知执行功能测试结果差异无统计学意义(P>0.05);相比对照组,长期戒断甲基苯丙胺依赖组右侧楔前叶、背外侧额上回、距状裂周围皮质及左侧颞下...

Objective: To explore the mechanism for changes in brain microstructure in long-term abstinent from methamphetamine-dependence by using the diffusion tensor imaging (DTI). Methods: A total of 26 patients with long-term abstinent methamphetamine-dependence, whose abstinence time more than 14 months, and 26 normal controls all underwent cognitive executive function tests and DTI scans. We used voxel-based analysis to compare the fractional anisotropy (FA) and mean diffusivity (MD) to obtain the abnormal brain regions of DTI parameters between the...