Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis

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成果类型：

期刊论文

作者：

Li, Tian-Ping;Sun, Shao-Wei;Xiong, Guo-Zuo;Qiu, Fei;Yang, Dong-Mei;...

通讯作者：

Tuo, Qin-Hui

作者机构：

[Chen, Jian-Xiong; Sun, Si-Yu; Qiu, Fei; Tuo, Qin-Hui; Xie, Xue-Jiao; Liao, Duan-Fang; Li, Tian-Ping; Yang, Dong-Mei] Hunan Univ Chinese Med, Med Sch, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Xiong, Guo-Zuo; Chen, Jian-Xiong; Li, Tian-Ping; Sun, Shao-Wei] Univ South China, Sch Pharmaceut Sci, Hengyang, Peoples R China.

[Chen, Jian-Xiong; Li, Tian-Ping] Sch Polytech Environm & Biol, Sch Pharmaceut Sci, Hengyang, Peoples R China.

[Chen, Jian-Xiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.

通讯机构：

[Tuo, Qin-Hui] H

Hunan Univ Chinese Med, Med Sch, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

3-Hydroxy-3-methylglutaryl-CoA reductase;Androgen receptor;Atherosclerosis;Cholesterol;Daxx;Sterol-regulatory element-binding proteins

期刊：

Pharmacology

ISSN：

0031-7012

年：

2021

卷：

106

期：

1-2

页码：

29-36

DOI：

10.1159/000506488

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Introduction: Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. Objective: The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and androgen receptor (AR) on intracellular cholesterol synthesis. Methods: HepG2 cells were transfected with pCDNA3.1(+)/Daxx plasmid or treated with testosterone propionate to observe the effects of Daxx and AR on intracellular cholesterol levels. Co-immunoprecipitation experiments wer...

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Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis

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