Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis

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成果类型：

期刊论文

作者：

Li, Tian-Ping;Sun, Shao-Wei;Xiong, Guo-Zuo;Qiu, Fei;Yang, Dong-Mei;...

通讯作者：

Tuo, QH

作者机构：

[Chen, Jian-Xiong; Sun, Si-Yu; Tuo, Qin-Hui; Qiu, Fei; Xie, Xue-Jiao; Liao, Duan-Fang; Li, Tian-Ping; Yang, Dong-Mei] Hunan Univ Chinese Med, Med Sch, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Xiong, Guo-Zuo; Chen, Jian-Xiong; Li, Tian-Ping; Sun, Shao-Wei] Univ South China, Sch Pharmaceut Sci, Hengyang, Peoples R China.

[Chen, Jian-Xiong; Li, Tian-Ping] Sch Polytech Environm & Biol, Sch Pharmaceut Sci, Hengyang, Peoples R China.

[Chen, Jian-Xiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.

通讯机构：

[Tuo, QH ] H

Hunan Univ Chinese Med, Med Sch, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

androgen receptor;AR protein, human;azo compound;chaperone;cholesterol;corepressor protein;DAXX protein, human;HMGCR protein, human;hydroxymethylglutaryl coenzyme A reductase;oil red O;SREBF2 protein, human;sterol regulatory element binding protein 2;biosynthesis;colorimetry;Hep-G2 cell line;high performance liquid chromatography;human;immunoprecipitation;metabolism;Azo Compounds;Cholesterol;Chromatography, High Pressure Liquid;Co-Repressor Proteins;Colorimetry;Hep G2 Cells;Humans;Hydroxymethylglutaryl CoA Reductases;Immunoprecipitation;Molecular Chaperones;Receptors, Androgen;Sterol Regulatory Element Binding Protein 2

期刊：

Research Reviews in Pharmacology

ISSN：

0031-7012

年：

2021

卷：

106

期：

1-2

页码：

29-36

DOI：

10.1159/000506488

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (81673722; 81603600), key projects of Hunan Education Department (16A156), Scientific Research Project of Hunan Health and Family Planning Commission (B20180049), and Hunan Provincial Natural Fund (2019JJ50426).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Introduction: Homeostasis of cholesterol is crucial for cellular function, and dysregulated cholesterol biosynthesis is a metabolic event that can lead to hepatic and cardiovascular abnormalities. Objective: The aim of this study was to investigate the effects and mechanisms of domain-associated protein (Daxx) and androgen receptor (AR) on intracellular cholesterol synthesis. Methods: HepG2 cells were transfected with pCDNA3.1(+)/Daxx plasmid or treated with testosterone propionate to observe the effects of Daxx and AR on intracellular choleste...

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Direct Interaction of Daxx and Androgen Receptor Is Required for Their Regulatory Activity in Cholesterol Biosynthesis

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