Kindlin-2 Mediates Lipopolysaccharide-Induced Acute Lung Injury Partially via Pyroptosis in Mice

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成果类型：

期刊论文

作者：

Huang, Yi-Dan;Fang, Yu;Ma, Li;Feng, Peng-Jiu;Li, Wen-Long;...

通讯作者：

You, Zhi-Jian;Dong, L

作者机构：

[Dong, Liang; You, Zhi-Jian; Qin, Yuan-Hao; Dong, L; Huang, Yi-Dan; Ma, Li; You, ZJ; Zhou, Yi-Qi; Li, Wen-Long] Liuzhou Municipal Peoples Hosp, Dept Anesthesiol, Liuzhou 545006, Guangxi, Peoples R China.

[Fang, Yu] Hunan Univ Chinese Med, Med Lab, Affiliated Hosp 1, Changsha 410021, Hunan, Peoples R China.

[Fang, Yu] Hunan Univ Chinese Med, Pathol Ctr, Affiliated Hosp 1, Changsha 410021, Hunan, Peoples R China.

[Feng, Peng-Jiu] Liuzhou Tradit Chinese Med Hosp, Dept Anesthesiol, Liuzhou 545001, Guangxi, Peoples R China.

通讯机构：

[Dong, L ; You, ZJ] L

Liuzhou Municipal Peoples Hosp, Dept Anesthesiol, Liuzhou 545006, Guangxi, Peoples R China.

语种：

英文

关键词：

acute lung injury;kindlin-2;inflammation;pyroptosis;endothelial cells

期刊：

Inflammation

ISSN：

0360-3997

年：

2022

卷：

期：

页码：

1199-1208

DOI：

10.1007/s10753-021-01613-w

基金类别：

High-level introduction of talent research start-up fund [LRYGCC202111, LRYGCC202108]; Self-funded scientific research project of Health Commission of Guangxi [Z20210219, Z20200052]; Guangxi Natural Science FoundationNational Natural Science Foundation of Guangxi Province [2020GXNSFAA297101]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Acute lung injury (ALI) is characteristic of the wholesale destruction of the lung endothelial barrier, which results in protein-rich lung edema, influx of pro-inflammatory leukocytes, and intractable hypoxemia, contributing to high mortality. Kindlin-2 is involved in the process of tumor- and wound healing-associated inflammation. However, the effects of kindlin-2 on lipopolysaccharide (LPS)-induced ALI and its mechanisms remain unknown. In this study, we found that the concentration of kindlin-2 was elevated in the lungs of ALI mice. The spec...

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Kindlin-2 Mediates Lipopolysaccharide-Induced Acute Lung Injury Partially via Pyroptosis in Mice

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