期刊论文

Abnormal expression of glypican-3 and ubiquitin D in hepatocellular carcinoma and the associated interaction

中文

解剖学报

0529-1356

2021

52

05

744-750

10.16098/j.issn.0529-1356.2021.05.011

2019年湖南省教育厅科学研究优秀青年项目（19B436）；

本校为第一机构

目的利用基因组学和表观遗传组学分析工具,分析磷脂酰肌醇蛋白聚糖3（GPC3）和泛素D（UBD）在肝细胞癌（HCC）中的异常表达情况,以及两者对HCC患者预后的影响。方法利用ULCAN（http://ualan.path.uab.edu）和Gene Expression Profiling Interative Analysis（GEPIA）数据库,分析UBD和GPC3在正常肝组织和HCC组织的异常表达情况和甲基化水平,以及对HCC患者生存的影响。利用Gene Cards数据库分析UBD和GPC3的定位。利用STRING数据库对UBD和GPC3分别构建蛋白质互相作用（PPI）网络,并对UBD和GPC3进行基因注释。基于皮尔森相关系数,计算UBD和GPC3在HCC发生发展中的关联。结果 UBD和GPC3在HCC组织中表达...

Objective To explore the abnormal expression of ubiquitin D(UBD) and glypican-3(GPC3) among patients of hepatocellular carcinoma (HCC) by using analysis tools of genomics and epigenetics,so as to study their prognostic effects.Methods The online tools called ULCAN(http: / /ualan.path.uab.edu) and Gene Expression Profiling Interative Analysis(GEPIA) were used to perform expression analysis in genomics and epigenetics of UBD and GPC3.Moreover,GEPIA was conducted to evaluate the survival effects on HCC patients.The GeneCards was used to find the localization of UBD and GPC3 in tumor tissue and no...