期刊论文

中文

中国药学：英文版

1003-1057

2022

31

2

117-133

General program of National Natural Science Foundation of China （Grant No. 81573941）； Open fund project for first-class disciplines of traditional Chinese Medicine （Grant No. 2021ZYX20）； Graduate research innovation project of Hunan Province （Grant No. CX20200798）；

本校为第一机构

脑缺血（cerebral ischemia, CI）具有高发病率、高致畸率,是全球第二大致死疾病。中药（traditional Chinese medicine,TCM）益气活血方（YQHX）在临床治疗CI发挥一定疗效,但其机制尚不清楚。本文基于网络药理学和分子对接探讨其作用机制。通过TCMSP和CNKI数据库获取益气活血方活性成分;利用Pharmmapper数据库获得成分靶点信息;检索OMIM、Gene Cards、DisGeNET数据库得到脑缺血的疾病靶点; Venn图得到交集靶点, Cytoscape可视化结果,插件MCODE获得核心靶点;使用Metascape数据库对核心靶点进行GO和KEGG通路富集分析;选取前20条KEGG通路富集通路用Cytoscape构建"成分-靶点-通路"图;排名前10的成分...

Cerebral ischemia (CI) is the world's second-largest lethal disease,with a high recurrence and teratogenic rate.Traditional Chinese medicine (TCM) YQHX (a pharmaceutical preparation from herbs) has a certain effect in the clinical treatment of CI,while its underlying mechanism remains largely undetermined.To explore the potential mechanism,we used network pharmacology and molecular docking in the present study.TCMSP and CNKI databases were used to explore the active ingredients of YQHX;the Pharmmapper database was used to get the ingredient targets;the OMIM,GeneCards,and DisGeNET databases wer...