期刊论文

中文

中国药学：英文版

1003-1057

2023

32

01

17-31

The Hunan Administration of Traditional Chinese Medicine（Grant No.2021017）； the Natural Science Foundation of Hunan Province（Grant No.2021JJ30419）； the Education Department of Hunan Province（Grant No.20B443）； the Changsha Science and Technology Plan other Science and Technology Innovation Platform Project（Grant No.kh2201062）； the Hunan Graduate Scientific Research Innovation Project（Grant No.2021CX29）；

本校为第一机构

基于网络药理学和分子对接技术,探讨白芍七物汤(BSQWD)治疗结直肠癌(CRC)的作用机制.利用中药系统药理学数据库及分析平台(TCMSP)筛选中药的有效成分和靶标,利用Cytoscape软件绘制综合靶标网络图.通过GeneCards、OMIM、PharmGKB、TTD和DrugBank数据库确定了潜在的CRC靶标.利用Cytoscape整合BSQWD的化学成分、靶标和疾病.通过STRING平台行蛋白-蛋白相互作用(PPI)分析.利用R行京都基因与基因组百科全书(KEGG)通路和基因本体(GO)分析,最后利用AutoDock和SYBYL-X 2.0进行分子对接.结果表明,7种药材中含有110种化学成分.CRC相关基因共9048个.BSQWD与184个靶基因相关.鉴定到Hub基因,分别为JUN、HSP90A...

In the present study,we investigated the mechanism of Baishao Qiwu Decotion(BSQWD)in the treatment of colorectal cancer(CRC)based on network pharmacology and molecular docking technology.The active components and all targets of traditional Chinese medicine(TCM)were screened by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the compositive target network diagram was drawn by Cytoscape software.Potential CRC targets were identified by GeneCards,OMIM,PharmGKB,TTD,and DrugBank databases.Cytoscape was used to integrate chemical components,targets,and...