会议论文

中文

2015

193

第六届中国医师协会感染科医师大会暨传染病诊治高峰论坛、第十四届中华预防医学会微生态学学术会议

第六届中国医师协会感染科医师大会暨传染病诊治高峰论坛、第十四届中华预防医学会微生态学学术会议论文集

2014-10-9

大连

中华预防医学会微生态学分会;中国医师协会感染科医师分会;浙江省医师协会感染科医师分会

本校为第一机构

目的:研究泼尼松对慢加急性肝衰竭模型大鼠肝内树突状细胞凋亡的影响及其与Axl信号的关系。方法:采用牛血清白蛋白致敏建立免疫性肝纤维化大鼠模型,然后用D-氨基半乳糖加脂多糖腹腔注射急性攻击建立慢加急性肝衰竭模型。同时用泼尼松灌胃治疗。检测急性攻击前及攻击后1小时、12小时血清肝功能,肝脏病理检测采用HE染色、CD11c/CD123+TUNEL凋亡双染色、CD11c/CD123+Axl-mRNA原位杂

　　Objective: To observe effects of prednisone on dendretic cells'(DC) apoptosis of acute-on-chronic liver failure (ACLF) rats and find out its relationship with Axl signal.Methods: Immunological hepatic fibrosis was induced by administration of bovine serum albumin to Wistar rats.D-galactosamine and lipopolysaccharide were simultaneously intraperitoneally injected to establish the ACLF models.Prednisone was dosed as treatment.Serum levels of liver function tests were detected on the time before the acute attack and 1 , 12 hours after the acut...