期刊论文

Peng, Qing-Hua

英文

国际眼科杂志：英文版

2222-3959

2010

3

1

203-208

10.3969/j.issn.1672-5123.2010.02.001

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30772824]; University Doctor Fund of Ministry of Education, ChinaMinistry of Education, China [200805410004]; Hunan Provincial Natural Science Fund of China [07JJ3049]; Scientific Research Fund of Hunan Provincial Science and Technology Department, China [2009FJ3001]; Hunan Provincial Master's Innovation Fund [28]

本校为第一且通讯机构

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目的:观察密蒙花提取物滴眼剂对去势所致干眼症雄鼠基础泪液分泌量、泪膜稳定性、泪腺中雄激素受体表达的影响,探讨密蒙花提取物滴眼剂抗雄激素水平下降所致干眼症的作用机制.方法:将45只Wister雄性大鼠随机分为空白组(A1、A2、A3)、模型组(B1、B2、B3)、密蒙花提取物滴眼剂治疗组(C1、C2、C3),共9组,1代表饲养1mo,2代表饲养2mo,3代表饲养3mo,每组5只,对B、C组行去势术建立动物模型,对C组以密蒙花提取物滴眼剂连续滴眼治疗1mo,对全部实验大鼠行Schirmer I试验、测量泪膜破裂时间,采用流式细胞仪检测泪腺中雄激素受体的表达.结果:C组Schirmer I试验测量值明显高于B组(P