期刊论文

Qin, Y.-H.

英文

国际眼科杂志

1672-5123

2015

15

1

30-33

10.3980/j.issn.1672-5123.2015.1.07

(81473737):国家自然科学基金项目 (No.13A072):湖南省教育厅科研基金重点项目 (81473737):National Natural Science Foundation of China (13A072):Key Project Research Foundation of Hunan Educational Committee

本校为第一且通讯机构

AIM: To observe the effects of Shuangdanmingmu capsule on VEGF expression and retinal vascular morphology in rats with diabetic retinopathy (DR). METHODS: DR rats were fed with Shuangdanmingmu capsule. By comparing with the normal group, the model control group, and positive control group, the effect of Shuangdanmingmu capsule on retinal tissue of DR rats was observed under electron microscopy. After HE staining, retinal structure was observed under the light microscope. Immunohitochemical staining was used to detect the VEGF expression in reti...

目的：：观察糖尿病视网膜病变大鼠模型视网膜血管的病理变化及VEGF表达变化,初步评价双丹明目胶囊抑制视网膜血管新生效应。方法：将双丹明目胶囊作用于糖尿病视网膜病变大鼠,通过与正常组、模型对照组、阳性对照组的比较,电镜下观察双丹明目胶囊对糖尿病视网膜病变大鼠视网膜组织的影响,HE染色后光镜下观察视网膜结构,并采用免疫组织化学法检测大鼠视网膜中VEGF的表达。结果：经双丹明目胶囊治疗2 mo后,双丹明目组大鼠视网膜组织轻度水肿,毛细血管周细胞水肿,线粒体轻度肿胀,结构稍欠清晰,部分内皮细胞轻度增生。除正常组外各组视网膜VEGF表达增加,以模型对照组最为明显,且双丹明目组和阳性对...