期刊论文

Qin, Y.-H.

中文

国际眼科杂志

1672-5123

2018

18

11

1958-1962

10.3980/j.issn.1672-5123.2018.11.03

Foundation items: National Natural Science Foundation of China (No. 81473737); Project of Hunan Postgraduate Research and Innovation ( No. CX2016B377, CX2017B432 ); Construction Project of Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Otorhinolaryngology in Hunan Province (No.2017TP1018); Science and Technology Project of Changsha (No. kc1704005); Construction Project of Local Universities Supported by Central Finance; Construction Project of Key Discipline of Traditional Chinese Medicine Ophthalmology of the State Administration of Traditional Chinese Medicine; Construction Project of Key Discipline of Traditional Chinese Medicine in Hunan Province 1Key Disciplines of Chinese Medicine Ophthalmology, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China;2Key Laboratory of Otorhinolaryngology of Traditional Chinese medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China Correspondence to: Yu - Hui Qin. Key Disciplines of Chinese Medicine Ophthalmology, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China; Key Laboratory of Otorhinolaryngology of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China. dlqyh@ sohu. com. Qing-Hua Peng. Key Disciplines of Chinese Medicine Ophthalmology, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China; Key Laboratory of Otorhinolaryngology of Traditional Chinese Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, China. pqh410007@ 126. com Received:2018-04-12摇 摇 Accepted:2018-09-29

本校为第一且通讯机构

目的:观察双丹明目胶囊对糖尿病大鼠模型视网膜VEGF家族因子VEGF-a、VEGF-b、VEGF-c蛋白表达的影响。方法:将40只雄性SD大鼠,采用随机数字法分为A空白组、B模型组、C双丹明目组、D阳性对照组4组,每组10只20眼。将B、C、D三组实验大鼠采用STZ 50mg/kg的剂量一次性大鼠尾静脉注射法建立糖尿病视网膜病变大鼠模型,造模后1wk开始连续灌胃用药,灌胃后4wk,处死动物,免疫组化法检测视网膜组织中VEGF-a、VEGF-b、VEGF-c的表达。结果:成模后用药第4wk,模型组、双丹明目组、阳性对照组视网膜中VEGF-a、VEGF-b、VEGF-c蛋白表达平均灰度值均低于正常组,平均光密度均高于正常组,其中模型组与正常组比较,差异均...

AIM: To study the effects of Shuangdan Mingmu capsule on the expressions of vascular endothelial growth factor-a (VEGF-a), VEGF-b, VEGF-c in the retina of a diabetic rat model. METHODS: Forty male SD rats were divided into Group A (normal group), Group B (model group), Group C (Shuangdan Mingmu group) and Group D (positive control group) 10 rats (20 eyes) in each group. A rat model of diabetic retinopathy was established by one-time tail vein injection with STZ (50mg/kg). After modeling for 1wk, the rats were given medicine by gavage. After gavage for 4wk rats were sacrificed, and the expressi...