期刊论文

Peng, Q.-H.

中文

国际眼科杂志

1672-5123

2020

20

3

426-431

10.3980/j.issn.1672-5123.2020.3.06

National Natural Science Foundation of China (No.30772824, 81574031); "225" Engineering Project of High Lever Health Professionals of Hunan Province [Xiang wei ren fa (2013) No.13]; Hunan Science and Technology Department Research Fund Project (No.2015SF2016-6); Hunan Province Development and Reform Commission Research Fund Project (Xiangfa Reform Investment [2014] No.658); Changsha Science and Technology Plan Major Project (No.K1501014-31); Hunan University of Chinese Medicine Graduate Innovation Project (No.2016CX19); Key Discipline Project of Ophthalmology of Traditional Chinese Medicine of State Administration of TCM (Traditional Chinese Medicine Fa [2009] No.30); The Domestic First-class Discipline Construction Project of Chinese Medicine of Hunan University (Xiang Jiao Tong[2018] No.469); Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine (No.2017TP1018); Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine (No.2018TP2008).

本校为第一且通讯机构

目的:观察不同浓度的密蒙花滴眼液对去势雄兔干眼结膜炎性因子IL-1β、黏蛋白5AC（MUC5AC）及P38MAPK表达的影响,从而探讨密蒙花滴眼液对干眼的疗效。方法:将36只雄兔随机分为:空白组、模型组、密蒙花滴眼液低浓度组（1mg/mL）、中浓度组（1.5mg/mL）、高浓度组（3mg/mL）、睾酮组。除空白组外各组均行睾丸及附睾切除建立干眼动物模型,造模成功后,空白组和模型组不予以处理,密蒙花滴眼液低浓度组（1mg/mL）、中浓度组（1.5mg/mL）、高浓度组（3mg/mL）给予密蒙花不同浓度滴眼液,3次/d,睾酮组按0.5mL/kg剂量在大腿肌肉处注射丙酸睾酮,每3d 1次,各组分别于造模前和用药4wk后在全身麻醉下检测荧光素...

AIM: To observe the effects of butterflybush flower eye drops at different concentrations on expression of inflammatory crtokines IL-1β, Mucin 5AC(MUC5AC) and P38MAPK in castrated male rabbits, and to explore the therapeutic effect of that drops on dry eyes. METHODS: Thirty-six male rabbits were randomly divided into blank group (A), model group (B), low concentrations butterflybush flower eye drops group (C, 1mg/mL), the medium concentrations drops group (D, 1.5mg/mL), the high concentrations drops group (E, 3mg/mL), and testosterone group (F...