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Progress in experimental research of retinitis pigmentosa [视网膜色素变性的实验研究进展]

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成果类型:
期刊论文
作者:
蒋鹏飞;彭俊;欧晨;姚震;田野;...
通讯作者:
Peng, Q.-H.
作者机构:
[欧晨; 蒋鹏飞; 姚震; 田野; 王英] Hunan University of Chinese Medicine, Changsha, Hunan Province 410208, China
Department of Ophthalmology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province 410007, China
Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, Hunan Province 410208, China
[彭俊] Department of Ophthalmology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province 410007, China, Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, Hunan Province 410208, China
[彭清华] Hunan University of Chinese Medicine, Changsha, Hunan Province 410208, China, Department of Ophthalmology, First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan Province 410007, China, Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, Hunan Province 410208, China
通讯机构:
[Peng, Q.-H.] H
Hunan University of Chinese MedicineChina
语种:
中文
关键词:
视网膜色素变性;实验研究;视网膜移植;基因治疗
关键词(英文):
Experimental study;Gene therapy;Retinal transplantation;Retinitis pigmentosa
期刊:
国际眼科杂志:英文版
ISSN:
2222-3959
年:
2020
卷:
20
期:
6
页码:
970-973
基金类别:
National Natural Science Foundation of China (No.81804150); Construction of Hunan Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of ENT diseases(No.2017TP1018); Changsha Science and Technology Planning Project(No.K1501014-31,kc1704005); Chinese Medicine Ophthalmology Key Subject Construction Project of the Administration of Traditional Chinese Medicine (No.ZK1801YK015); Hunan University of Chinese Medicine First-class Construction Subject of Chinese Medicine; Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine; Chinese Medicine Prevention and Treatment of Eye Diseases and Visual Function Protection Hunan Engineering Research Center, Hunan Postgraduate Research and Innovation Project (No.CX2018B497); Natural Science Foundation of Hunan Province (No.2019JJ40226); Open Fund Project of the Innovation Platform of Hunan Provincial Department of Education (No.16K065); Postgraduate Innovation Project of Hunan University of Traditional Chinese Medicine (No.2018CX40).
机构署名:
本校为第一且通讯机构
院系归属:
第一中医临床学院
摘要:
视网膜色素变性是一种遗传性眼病,遗传方式包括常染色体显性遗传、常染色体隐性遗传及性连锁隐性遗传等,目前已知的突变位点超过3 000个,造成本病临床治疗困难。眼科学者致力于探索视网膜色素变性的治疗方式,进行了大量实验研究,主要有药物治疗、细胞移植、基因治疗等治疗方式。药物治疗包括中药、抗氧化剂、抗凋亡剂、神经营养因子等,与其它治疗方式相比,无侵入性,且方便价廉,但其作用机制尚需更深入的研究。细胞移植被认为是治疗视网膜色素变性的有效方法,但有可能引起视网膜前膜及黄斑皱褶。基因治疗虽然存在一定的局限性,但随着基因编辑技术和新型基因递送载体的发展,未来会成为视网膜色素变...
摘要(英文):
Retinitis pigmentosa is an inherited eye disease. The inheritance methods include autosomal dominant inheritance, autosomal recessive inheritance, and sex-linked recessive inheritance. Currently, there are more than 3,000 mutation sites, which makes clinical treatment of this disease difficult. Ophthalmologists are committed to exploring the treatment of retinitis pigmentosa, and have conducted a large number of experimental studies, mainly including drug treatment, cell transplantation, gene therapy, etc. Drug therapy includes traditional Chinese medicine, antioxidants, anti-apoptotic agents,...

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