期刊论文

Yang, Y.-B.

中文

中国药理学通报

1001-1978

2003

19

4

388-392

10.3321/j.issn:1001-1978.2003.04.007

国家 973项目NoG2 0 0 0 0 56 90 5 国家自然科学基金资助课题No 39970 84 7

本校为第一机构

目的：研究普罗布考抗动脉成形术后再狭窄与其调节功能性血管重构的方法。方法：用3．5F球囊导管构建兔动脉粥样硬化动脉成形术后再狭窄模型。动脉成形术2wk后取其胸主动脉，固定染色并进行计算机图像分析；观察血管环对乙酰胆碱诱导的舒张百分率，然后再观察其对内源性收缩物质去甲肾上腺素（NA）、KCl以及5－羟色胺（5－HT）的收缩反应性。同时，在动脉成形术2wk后留其血清，观察普罗布考对动脉成形术后血清一氧化氮（NO）含量的影响。结果：普罗布考明显增加血管管腔面积，减少新生内膜面积；可保护动脉成形术后血管的舒张功能，保护内皮细胞合成与释放内皮源性舒张因子NO，降低血管对内源性...

AIM To investigate the relationship between the prevention of probucol against restenosis and functional vascular remodeling after percutaneous transluminal angioplasty(PTA) in rabbits. METHODS New Zealand rabbit thoracic aorta atherosclerosis was induced by 3 5 F balloon catheter injury following a 4 week feeding of high cholesterol diet, and percutaneous transluminal angioplasty(PTA) was performed by using 3 5 F ballon catheter. Probucol(1 g·d -1 ) or vitamin E(400 mg·d -1 ) was administrated one week before PTA. Two weeks after PTA, lumen ...