期刊论文

Preventive and therapeutic effect of buyang huanwu decoction on denervated tibial muscle atrophy of rats

Zhou, L.

中文

中国药理学通报

Chinese Pharmacological Bulletin

1003-0603

2010

26

3

401-405

国家自然科学基金面上项目

本校为其他机构

目的 研究补阳还五汤(BYHWD)对大鼠胫前肌失神经肌萎缩的防治作用.方法 建立大鼠腓总神经夹伤模型,将造模后的60只♂ SPF级SD大鼠随机分为6组:BYHWD 高、中、低剂量组、弥可保组、模型组、假手术组,术后每日灌胃给药.术后18 d,病理切片染色. 形态学分析,计算胫前肌湿重比和横截面积.结果 假手术组胫前肌横截面积较大,形态规则;模型组横截面积明显减小,结构紊乱,结缔组织明显增生;BYHWD各组与弥可保组横截面积较小,形态较规则,结缔组织增生不明显.与模型组相比,BYHWD各组胫前肌横截面积明显增加(P

Aim: To study the preventive and therapeutic effects of Buyang Huanwu Decoction (BYHWD) on denervated tibial muscle atrophy of rats. Methods: After 60 Sprague-Dawley rats were subjected to Common Peroneal nerve crush model of 5 mm injury, they were randomly divided into 6 groups for daily intragastric administration of drugs: BYHWD high-dose, medium-dose, low-dose groups, mecobalamin group (positive control), model group, sham operation group. The drug administration lasted for 18 days. 18 days after operation, slice, masson staining and analysis morphology were performed. The wet weight ratio...