期刊论文

Research advances of roles of Th17 cells in pathogenesis of rheumatoid arthritis

中文

中国药理学通报

1001-1978

2020

36

3

309-312

10.3969/j.issn.1001-1978.2020.03.004

No81803993:国家自然科学基金 81704065:国家自然科学基金 No2017JJ3239:湖南省自然科学基金 2018JJ3392:湖南省自然科学基金 2018JJ2293:湖南省自然科学基金 2019JJ40225:湖南省自然科学基金 No17K069:湖南省教育厅创新平台开放基金

本校为第一机构

类风湿关节炎(rheumatoid arthritis,RA)是临床常见炎症性自身免疫疾病,以早期进行性关节滑膜炎症为主要临床特征,晚期则多以关节软骨破坏及骨侵蚀为主要病理特征。RA病因复杂,病理机制至今未明,发病率高,5年期致残率高。Th17细胞作为CD4 + T细胞的亚群之一,其分泌的IL-17、IL-21等促炎性细胞因子,在RA关节滑膜炎症和关节软骨破坏及骨侵蚀等多个病理环节均发挥重要作用。基于此,本文对近年来Th17细胞参与RA关节滑膜炎症和关节软骨破坏及骨侵蚀病程的相关研究文献进行综述和讨论,以期为RA发病机制研究提供新思路,为以Th17细胞为作用靶点的创新药物开发提供参考。

Rheumatoid arthritis ( RA) is a common immune-mediated inflammatory autoimmunity disease. In the early stage of RA,progressive joint synovial chronic inflammation is the main clinical feature, and in the later period, RA has led to articular cartilage destruction and bone erosion eventually. The etiology of RA remains elusive, and its pathogenesis involves complex immune and inflammatory pathways. The morbidity and 5-year disability rate of RA are both higher than those of other diseases. Thl 7 cells, one of subsets of CD4+T cells, secrete pro-...