期刊论文

The protective effect of borneol combined with astragaloside Ⅳ and panax notoginseng saponins on neurovascular units after cerebral ischemia/reperfusion injury

中文

中国药理学通报

1001-1978

2020

36

10

1470-1476

10.3969/j.issn.1001-1978.2020.10.025

国家自然科学基金项目(No 81573875) 湖南省自然科学创新群体基金 湖南省科技厅科技创新平台与人才计划资助项目(No 2017SK4005) 湖南省科技厅重点专项资助(No 2017SK2111) 湖南省自然科学基金(No 2018JJ3382) 湖南省教育厅优秀青年项目(No 18B236) 湖南中医药大学“十三五”一级学科基础医学建设项目(No 06)。

本校为第一机构

目的观察冰片配伍黄芪甲苷(astragaloside Ⅳ,AST Ⅳ)和三七总皂苷(panax notoginseng saponins,PNS)对大鼠脑缺血/再灌注后神经血管单元(NVU)的保护作用。方法脑缺血/再灌注大鼠灌胃给药,测定神经功能缺损、脑梗死体积和海马CA1区胶质纤维酸性蛋白(GFAP)、神经元特异性核蛋白(NeuN)、层黏连蛋白(LN)、水通道蛋白-4(AQP-4)及基质金属蛋白酶9(MMP-9)表达。结果冰片配伍AST Ⅳ和PNS能显著改善大鼠神经功能评分(P

Abstract; Aim To investigate the protective effect of borneol combined with astragaloside IV and panax no- toginseng saponins on neurovascular unit(NVU) after cerebral ischemia/reperfusion injury in rats. Methods Rats with cerebral ischemia/reperfusion were administered by gavage, the symptom of nerve function defect was observed, and the volume of cerebral infarction, and the expression of glial fibrillary acidic protein (GFAP), neuron specific nuclear ( NeuN ),Laminin (LN) , aquaporin-4( AQPA) and matrix metalloprotei- nase-9(MMP-9) in hippoc...