期刊论文

Effect of Liuwei Dihuang decoction onβ-catenin and EMT in kidney tissue of UUO rats

中文

中国药理学通报

1001-1978

2023

39

12

2385-2389

10.12360/CPB202302069

湖南省自然科学基金项目(No 2021JJ30506)。

本校为第一机构

目的探讨六味地黄汤(Liuwei Dihuang decoction,LWDHD)对单侧输尿管梗阻(unilateral ureteric obstrutction,UUO)大鼠肾组织中上皮钙黏蛋白E(E-cadheri...展开更多 目的探讨六味地黄汤(Liuwei Dihuang decoction,LWDHD)对单侧输尿管梗阻(unilateral ureteric obstrutction,UUO)大鼠肾组织中上皮钙黏蛋白E(E-cadherin)、β-连环蛋白(β-catenin)、α-平滑肌肌动蛋白(α-SMA)的表达、肾脏组织病理变化及上皮-间质转化(epithelial-mesenchymal transformation,EMT)的影响。方法SPF级SD大鼠48只随机分成假手术组(Sham)、模型组(UUO)、LWDHD低、中、高组(LWDHD 3.375、6.75、13.5 g·kg-1)、依那普利...

Aim To explore the effect of Liuwei Dihuang decoction(LWDHD)on the expression ofβ-catenin,E-cadherin,α-SMA,the pathological changes of renal tissue,and the changes of an epithelial-mesenchymal transformation(EMT)in renal tissue of rats with unilateral ureteral obstructi...MORE Aim To explore the effect of Liuwei Dihuang decoction(LWDHD)on the expression ofβ-catenin,E-cadherin,α-SMA,the pathological changes of renal tissue,and the changes of an epithelial-mesenchymal transformation(EMT)in renal tissue of rats with unilateral ureteral obstruc...