期刊论文

Luo, Zi-Qiang

英文

European Journal of Medicinal Chemistry

0223-5234

2014

79

391-398

10.1016/j.ejmech.2014.04.026

Science Research Foundation for Higher Universities of Hunan Province [10A092]; Research Based Learning and Innovation Experiment Project for Undergraduates of Hunan Province [2011-483]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21003040]; Program for Changjiang Scholars and Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1238]; Program for New Century Excellent Talents in UniversitiesProgram for New Century Excellent Talents in University (NCET) [NCET-10-0371]

本校为其他机构

Three heterocyclic hypervalent organoantimony chlorides RN(CH2C6H4)(2)SbCI (2a R = t-Bu, 2b R = Cy, 2c R = Ph) and their chalcogenide derivatives [RN(CH2C6H4)(2)Sb](2)O (3a R = t-Bu, 3b R = Cy, 3c R = Ph) were synthesized and characterized by techniques such as H-1 NMR, C-13 NMR, X-ray diffraction, and elemental analysis. It is found that the anti-proliferative activity detected over these compounds can be attributed to the coordination bond between the antimony and nitrogen atoms of these compounds. Moreover, a preliminary study on mechanistic action suggests that the inhibition effect is asc...