Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway

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成果类型：

期刊论文

作者：

Song, Houpan;Zeng, Meiyan;Chen, Xiaojuan;Chen, Xinyi;Peng, Jun;...

通讯作者：

Peng, Qinghua;Cai, Xiong

作者机构：

[Chen, Xiaojuan; Chen, Xinyi; Peng, Qinghua; Lin, Ye; Song, Houpan] Hunan Univ Chinese Med, Inst Tradit Chinese Med Diagnost, Changsha, Hunan, Peoples R China.

[Chen, Xiaojuan; Chen, Xinyi; Yu, Rong; Lin, Ye; Zeng, Meiyan; Song, Houpan] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha, Hunan, Peoples R China.

[Peng, Jun] Hunan Univ Chinese Med, Affiliated Hosp 1, Dept Ophthalmol, Changsha, Hunan, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Chinese Med, Inst Innovat & Appl Res, Changsha, Hunan, Peoples R China.

通讯机构：

[Peng, Qinghua; Cai, Xiong] H

Hunan Univ Chinese Med, Inst Tradit Chinese Med Diagnost, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Chinese Med, Inst Innovat & Appl Res, Changsha, Hunan, Peoples R China.

语种：

英文

期刊：

Evidence-Based Complementary and Alternative Medicine

ISSN：

1741-427X

年：

2020

卷：

2020

DOI：

10.1155/2020/6538156

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81703920, 81804150]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M662790]; Hunan Provincial Natural Science FoundationNatural Science Foundation of Hunan Province [2019JJ50442, 2018JJ2293]; Hunan Education Department's Science and Research Project [17K069]; Hunan Provincial Science and Research Project of Chinese Medicine [201780]; Research-Based Learning and Innovative Experiment Program Project for Hunan University Students [2017280]; Open-Ended Science Foundation of Institute of Innovation and Applied Research in Chinese Medicine [201903]; 121 Hunan Provincial Training Project for Innovative Talents; National First-Class Disciple Construction Project of Chinese Medicine [2018ZYX20, 2018ZYX26]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

第一中医临床学院

摘要：

Background. Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) often causes small intestinal ulcers in patients, but few effective drugs are currently available to manage such serious adverse events of NSAIDs. Li-Zhong decoction (LZD), a well-known traditional Chinese medicine (TCM) formula, is commonly prescribed for treatment of gastrointestinal diseases. The present study aimed to investigate the anti-ulcerogenic activity of LZD on indomethacin- (IND-) induced duodenal ulcer in rats. Mechanistic studies of action of LZD were focused on involvement of TLR-2/MyD88 signaling pathw...

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Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway

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