miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic Vascular Smooth Muscle Cell Proliferation

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Shunmin;Tang, Lujun;Zhou, Qian;Lu, Duomei;Duan, Wulei;...

通讯作者：

Tan, Yuansheng

作者机构：

[Tang, Lujun; Zhou, Qian; Chen, Cheng; Lu, Duomei; Duan, Wulei; Wang, Shunmin] Hunan Univ Chinese Med, Grad Inst, Changsha, Hunan, Peoples R China.

[Huang, Lu; Wang, Shunmin] Hunan Univ Chinese Med, Hosp 1, Dept Cardiovasc, Changsha, Hunan, Peoples R China.

[Tan, Yuansheng] Hunan Acad Chinese Med, Coll Tradit Chinese Med 1, Dept Cardiovasc, Changsha, Hunan, Peoples R China.

[Tan, Yuansheng] Hunan Acad Chinese Med, Coll Integrated Tradit Chinese & Western Med, Dept Cardiovasc, Changsha, Hunan, Peoples R China.

[Tan, Yuansheng] Hunan Univ Chinese Med, Hanpu Sci & Technol Pk, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Tan, Yuansheng] H

Hunan Univ Chinese Med, Hanpu Sci & Technol Pk, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

miR-185;human aortic vascular smooth muscle cells;angiotensin II;P2Y6;proliferation;hypertension

期刊：

DNA and Cell Biology

ISSN：

1044-5498

年：

2017

卷：

期：

页码：

377-385

DOI：

10.1089/dna.2016.3605

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473616]; Science and Technology Program Major Project of China Hunan Provincial Science & Technology Department [2016DK2002]; Hunan Traditional Chinese Medicine Scientific Research Key Project [201753]

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

中西医结合学院

研究生院

摘要：

The abnormal proliferation and apoptosis of human aortic vascular smooth muscle cells (HAVSMCs) play an important role in the pathogenesis of hypertension. Recent study revealed that angiotensin II (Ang II) could elicit HAVSMC dysfunction, to induce or aggravate hypertension. Purinergic receptor P2Y6, an inflammation-inducible G protein-coupled receptor, promoted Ang II-induced hypertension. In the present study, we revealed that Ang II induced HAVSMC proliferation and upregulated P2Y6 protein levels. After knockdown of P2Y6, the promotive effe...

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miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic Vascular Smooth Muscle Cell Proliferation

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