Cytoplasmic M-CSF facilitates apoptosis resistance by inhibiting the HIF-1/BNIP3/Bax signalling pathway in MCF-7 cells

首页 > 成果 > 详情

认领

导出

Link by 万方学术期刊

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Mengxia;Liu, Qi;Li, Lijun;Ning, Jing;Tu, Jian;...

通讯作者：

Tang, Shengsong

作者机构：

[Zhang, Mengxia] Hunan Univ Chinese Med, Dept Histol & Embryol, Changsha 410208, Hunan, Peoples R China.

[Tang, Shengsong] Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.

[Zhang, Mengxia; Liu, Qi; Mo, Zhongcheng] Univ South China, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Shengsong; Lei, Xiaoyong; Tu, Jian; Li, Lijun] Univ South China, Insitute Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Ning, Jing; Tang, Shengsong] Hunan Univ Med, Dept Pharmacol, Huaihua 418000, Hunan, Peoples R China.

通讯机构：

[Tang, Shengsong] H

Hunan Univ Med, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Hunan, Peoples R China.

语种：

英文

关键词：

macrophage colony-stimulating factor;breast cancer;apoptosis;HIF-1 and BINP3

期刊：

Oncology Reports

ISSN：

1021-335X

年：

2019

卷：

期：

页码：

1807-1816

DOI：

10.3892/or.2018.6949

基金类别：

Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183]; Science and Technology Plan Key Projects of Hunan Province [10A087]; Hunan Provincial Natural Science Key Foundation of Hunan [09JJ3060]

机构署名：

本校为第一机构

院系归属：

医学院

中医学院

摘要：

Macrophage colony-stimulating factor (M-CSF), a tumour marker, is related to tumour cell anti-apoptosis and drug resistance. However, the role of M-CSF in MCF-7 cells is unknown. In the present study, the effect and mechanism of M-CSF on hypoxia-inducible factor-1 (HIF-1)/BCL2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3)/Apoptosis Regulator BAX signalling in human breast cancer MCF-7 cells were investigated. Western blotting revealed that the expression of HIF-1, BNIP3, Bax, caspase-3 and caspase-9 was lower in MCF-7-M cells compared to MCF-7 and MCF-7-C cells treated with adriamycin (A...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Cytoplasmic M-CSF facilitates apoptosis resistance by inhibiting the HIF-1/BNIP3/Bax signalling pathway in MCF-7 cells

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问