Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

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成果类型：

期刊论文

作者：

Zhang, P.;Du, H. B.;Tong, G. D.;Li, X. K.;Sun, X. H.;...

通讯作者：

Zhou, D. Q.;Ye, Y. A.;Gao, Y. Q.

作者机构：

[Zhang, P.; Du, H. B.; Ye, Y. A.; Li, X. K.; Jiang, F.] Beijing Univ Chinese Med, Affiliated Dongzhimen Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China.

[Zhang, P.; Du, H. B.; Ye, Y. A.; Yang, X. Z.; Li, X. K.; Jiang, F.] Beijing Univ Chinese Med, Affiliated Dongzhimen Hosp, Inst Liver Dis, Beijing, Peoples R China.

[Xing, Y. F.; Zheng, Y. J.; Zhou, D. Q.; Tong, G. D.] Shenzhen Hosp Tradit Chinese Med, Dept Hepatol, Shenzhen, Guangdong, Peoples R China.

[Sun, X. H.; Gao, Y. Q.; Zhou, Z. H.; Zhao, G.] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Hepatol, Shanghai, Peoples R China.

[Chi, X. L.; Jiang, J. M.; Tian, G. J.] Guangdong Hosp Tradit Chinese Med, Dept Hepatol, Guangzhou, Guangdong, Peoples R China.

通讯机构：

[Zhou, D. Q.; Gao, Y. Q.] S

[Ye, Y. A.] B

Shenzhen Hosp Tradit Chinese Med, Dept Hepatol, Shenzhen, Guangdong, Peoples R China.

Beijing Univ Chinese Med, Affiliated Dongzhimen Hosp, Inst Liver Dis, Dept Gastroenterol & Hepatol, Beijing, Peoples R China.

Shuguang Hosp, Dept Hepatol, Shanghai, Peoples R China.

语种：

英文

关键词：

affecting factor;HBsAg;HBV infection;multicentre trial;natural history

期刊：

Journal of Viral Hepatitis

ISSN：

1352-0504

年：

2018

卷：

期：

页码：

1017-1025

DOI：

10.1111/jvh.12903

基金类别：

National Science and Technology Major Project [2012ZX10005004, 2012ZX10005006]

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large-sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n = 588), HBeAg-positive chronic hepatitis B (n =...

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Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

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