期刊论文

Effect of Aerobic Exercise Training Combined with Furosemide on NT-proBNP and TNF-α of Heart Failure Rats

中文

湖南中医药大学学报

1674-070X

2014

34

10

11-14

10.3969/j.issn.1674-070X.2014.10.003.011.04

81373550:国家自然科学基金 2013ZYZD05:中医诊断学国家重点学科开放基金 2014ZYZD07:中医诊断学国家重点学科开放基金 CXJD20140004:湖南省运动科学研究生培养创新基地开放基金

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目的 观察有氧运动联合药物治疗方案对心衰大鼠脑钠肽前体(NT-proBNP)及肿瘤坏死因子-α(TNF-α)的影响机制.方法 将50只SD大鼠随机分为正常对照组(10只)与模型组(40只),模型组采用阿霉素腹腔注射7周造模,每周0.75 mL/kg,注射2次,共21 mg/kg.造模成功后,随机分为心衰模型组、呋塞米治疗组、有氧运动治疗组、运动呋塞米合治组.分别用生理盐水、呋塞米、有氧运动、有氧运动联合呋塞米干预4周,再从腹主动脉采血,离心后提取上清液,用ELISA法检测NT-proBNP与TNF-α.结果 与正常对照组比较,其他4组NT-proBNP与TNF-α明显增高,差异有统计学意义(P＜0.01);与心衰模型组比较,NT-proBNP与TNF-α在有氧运动...

Objective Observe the effect aerobic exercise training combined with drug on N-terminal pro-brain natriuretic peptide （NT-proBNP） and tumor necrosis factor-a （TNF-a） of heart failure rats and its mechanism. Methods 50 SD rats were randomly divided into normal control group （10） and model group （40）, the model groups were injected intraperitoneally for seven weeks of doxorubicin, 0.75 mL/kg×2 per week, and a total of 21 mg/kg. Then it were randomly divided into heart failure model group, furosemide therapy group, aerobic exercisetherapy...