期刊论文

Toxicological assessment of fresh pressed oil-tea camellia seed oil

中文

中国油脂

1003-7969

2020

45

03

68-73,97

10.12166/j.zgyz.1003-7969/2020.03.015

2018年度湖南省科技重大专项（2018NK1030）；

本校为第一机构

通过急性毒性试验、遗传毒性试验和亚急性毒性试验对鲜榨山茶油进行毒理学研究,并做安全性评价。结果表明:鲜榨山茶油对大鼠的急性经口LD_(50)大于10 000 mg/kg,判属实际无毒级;遗传毒性试验(Ames试验、小鼠骨髓细胞微核试验和体外哺乳类细胞染色体畸变试验)结果均为阴性;在大鼠28 d喂养试验中未见动物健康状况、血液生化指标和器官组织形态的异常变化。因此,鲜榨山茶油无急性毒性、遗传毒性和亚急性毒性,具有较高的食用安全性。

Acute toxicity test,genetic toxicity tests and sub-acute toxicity test of fresh pressed oil-tea camellia seed oil were performed to evaluate its safety.The results showed that acute toxicity test in rats demonstrated actual non-toxicity of fresh pressed oil-tea camellia seed due to its LD_(50) higher than 10 000 mg/kg.The results of genotoxicity tests (Ames test,mouse bone marrow cells micronucleus test and mammalian cell chromosome aberration test in vitro) were negative.No abnormal changes of animal health,biochemical indexes of blood and organ morphology were found in the 28 d feeding test ...