Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury

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成果类型：

期刊论文

作者：

Tian, Haomei;Zhang, Hong;Zhu, Junbao;Zhang, Juan;Cai, Hening;...

通讯作者：

Chen, Chutao

作者机构：

[Tian, Haomei; Zhang, Hong] Hunan Univ Tradit Chinese Med, Key Lab Meridians & Viscera, Changsha 410007, Hunan, Peoples R China.

[Chen, Chutao] Hunan Univ Tradit Chinese Med, Lab Acupuncture Bioinformat, Changsha 410007, Hunan, Peoples R China.

[Zhu, Junbao] Liuzhou Hosp Tradit Chinese Med, Liuzhou 545001, Guangxi Zhuang, Peoples R China.

[Zhang, Juan] Ningxiang Hosp Tradit Chinese Med, Ningxiang 410600, Hunan, Peoples R China.

[Cai, Hening; Zhang, Yuchen] Hunan Univ Tradit Chinese Med, Postgrad Coll, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Chen, Chutao] H

Hunan Univ Tradit Chinese Med, Lab Acupuncture Bioinformat, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

acupuncture;cerebral ischemia;Dazhui;Baihui;Renzhong;protein-chip technology;signal-transduction pathways;nerve injury;brain injury;ischemic injury;neural regeneration

关键词(中文)：

信号转导通路;缺血再灌注损伤;激活蛋白;针灸治疗;脑组织;修复;磷酸化蛋白;信号通路

期刊：

中国神经再生研究：英文版

ISSN：

1673-5374

年：

2012

卷：

期：

页码：

1866-1872

DOI：

10.3969/j.issn.1673-5374.2012.24.004

基金类别：

National Natural Science Foundation of China for YouthNational Natural Science Foundation of China (NSFC) [201130901901]; Youth Fund Project of the Ministry of Education of China [11B092]

机构署名：

本校为第一且通讯机构

院系归属：

针灸推拿与康复学院

研究生院

摘要：

A middle cerebral artery occlusion-model was established in rats using the improved thread embolism method.Rats were treated with acupuncture at either Dazhui(DU14),Renzhong(DU26), Baihui(DU20),or a non-meridian point.Detection with protein-chip technology showed that the level of protein phosphorylation in both groups was upregulated or downregulated depending on the signaling pathway compared with the model group that did not receive acupuncture.Analysis of proteins showing downregulated phosphorylation revealed that five signaling pathways were activated in the acupuncture-treatment group,w...

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Acupuncture activates signal transduction pathways related to brain-tissue restoration after ischemic injury

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