Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil
[Yao, Xiaoxuan; Qin, Ren'an] Hutchison Whampoa Guangzhou Baiyunshan Chinese Me, Modern Chinese Med Res Inst, Guangzhou 510515, Guangdong, Peoples R China.
supported by the Bureau of Traditional Chinese Medicine of Guangdong Province, No. 2010463
the National Science and Technology“12~（th） Five-years”Major Special-purpose Foundation,No.2011ZX09201-201-01
机构署名：
本校为通讯机构
院系归属：
第一中医临床学院
摘要：
After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer's disease. The cell model was treated with donepezil or compound Danshen tablets after culture for 72 hours. Reverse transcription-PCR showed that the mRNA expression of amyloid protein precursor decreased in all groups following culture for 24 hours, and that there was no significant difference in the amount of decrease between donepezil and compound Danshen tablets. Our results suggest that compound Danshen tablets can reduce expression of the mRNA for amyloid protein...
