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Huoxue Rongluo Tablet reduces matrix metalloproteinase-9 expression in infarcted brain tissue

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成果类型:
期刊论文
作者:
Zhou, Desheng;Li, Mei*;Hu, Hua;Chen, Yao;Yang, Yang;...
通讯作者:
Li, Mei
作者机构:
[Hu, Hua; Liu, Lijuan; Zhou, Desheng; Zhong, Jie; Chen, Yao] Hunan Univ Chinese Med, Hosp 1, Dept Neurol, Changsha 410007, Hunan, Peoples R China.
[Li, Mei] Pingxiang Hosp Tradit Chinese Med, Dept Internal Med, Pingxiang 337000, Jiangxi, Peoples R China.
[Yang, Yang] Fujian Univ Tradit Chinese Med, Peoples Hosp, Dept Neurol, Fuzhou 350004, Fujian Province, Peoples R China.
通讯机构:
[Li, Mei] P
Pingxiang Hosp Tradit Chinese Med, Dept Internal Med, Pingxiang 337000, Jiangxi, Peoples R China.
语种:
英文
关键词:
neural regeneration;traditional Chinese medicine;Huoxue Rongluo Tablet;cerebral infarction;neuroprotection;matrix metal oproteinase-9;buflomedil pyridoxal phosphate;grants-supported paper;neuroregeneration
关键词(中文):
基质金属蛋白酶;平板电脑;活血;脑组织;大鼠模型;磷酸吡哆醛;神经功能;蛋白表达
期刊:
中国神经再生研究:英文版
ISSN:
1673-5374
年:
2013
卷:
8
期:
34
页码:
3216-3224
基金类别:
supported by the Scientific Research Project of Traditional Chinese Medicine of Hunan Province Chinese Medicine Research Administration Bureau in China,No.201136;
机构署名:
本校为其他机构
院系归属:
第一中医临床学院
摘要:
Huoxue Rongluo Tablet was made of tal gastrodis tuber, dahurian angelica root, honeysuckle stem, grassleaf sweetflag rhizome, common flowering quince fruit, figwort root, red peony root and peach seed at a ratio of 3:2:6:2:3:3:3:3. Huoxue Rongluo Tablet is a wel-established and common pre-scription for the treatment of cerebral infarction. In this study, a rat model of cerebral ischemia was established and the animals were intragastrical y administered Huoxue Rongluo Tablet. This treat-ment reduced infarct volume, decreased matrix metal oproteinase-9 expression, and improved neurological funct...

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