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Electroacupuncture reduces apoptotic index and inhibits p38 mitogen-activated protein kinase signaling pathway in the hippocampus of rats with cerebral ischemia/ reperfusion injury

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成果类型:
期刊论文
作者:
Lan, Xiao;Zhang, Xin;Zhou, Guo-ping*;Wu, Chun-xiao;Li, Chun;...
通讯作者:
Zhou, Guo-ping
作者机构:
[Xu, Xiu-hong; Zhou, Guo-ping; Wu, Chun-xiao; Lan, Xiao] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China.
[Zhang, Xin; Li, Chun] Hunan Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Changsha, Hunan, Peoples R China.
通讯机构:
[Zhou, Guo-ping] S
Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China.
语种:
英文
关键词:
nerve regeneration;brain injury;electroacupuncture;cell apoptosis;cerebral ischemia/reperfusion injury;neurological impairment score;morphological changes;immunohistochemical assay;p38 mitogen-activated protein kinases;phosphorylated p38;hippoca
关键词(中文):
P38丝裂原活化蛋白激酶;MAPK信号通路;缺血再灌注损伤;电针治疗;细胞凋亡;脑缺氧;大鼠脑;缺血/再灌注损伤
期刊:
中国神经再生研究:英文版
ISSN:
1673-5374
年:
2017
卷:
12
期:
3
页码:
409-416
基金类别:
supported by the National Natural Science Foundation of China,No.81173355,Acknowledgments: The authors thank all the researchers involved in an- imal experiments, and are grateful to all staffs from Experimental Animal Center of Southern Medical University in China.
机构署名:
本校为其他机构
院系归属:
针灸推拿与康复学院
摘要:
Electroacupuncture attenuates cerebral hypoxia and neuronal apoptosis induced by cerebral ischemia/reperfusion injury. To further identify the involved mechanisms, we assumed that electroacupuncture used to treat cerebral ischemia/reperfusion injury was associated with the p38 mitogen-activated protein kinase (MAPK) signaling pathway. We established rat models of cerebral ischemia/reperfusion injury using the modified Zea-Longa's method. At 30 minutes before model establishment, p38 MAPK blocker SB20358 was injected into the left lateral ventricles. At 1.5 hours after model establishment, elec...

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