Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetesrelated depression

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成果类型：

期刊论文

作者：

Jian Liu;Yuan-Shan Han;Lin Liu;Lin Tang;Hui Yang;...

通讯作者：

Wang, YH

作者机构：

Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Inst Innovat & Appl Res, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Key Lab Chinese Mat Med Power & Innovat Drugs Est, Changsha, Hunan, Peoples R China.

Hunan Univ Chinese Med, Domest First Class Construct Discipline Chinese M, Changsha, Hunan, Peoples R China.

[Lin Liu; Jian Liu; Yuan-Shan Han; Pan Meng; Yu-Hong Wang; Hong-Qing Zhao; Hui Yang; Lin Tang] 湖南中医药大学

通讯机构：

[Wang, YH ] H

Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

caspase 3;caspase 9;corticosterone;dexamethasone;excitatory amino acid transporter 1;glial cell line derived neurotrophic factor;glial fibrillary acidic protein;glucocorticoid receptor;glucose;glutamic acid;metabotropic receptor 2;metabotropic receptor 3;mitogen activated protein kinase;phosphatidylinositol 3 kinase;platelet endothelial cell adhesion molecule 1;vesicular glutamate transporter 3;animal experiment;animal model;Article;astrocyte;brain capillary endothelial cell;capillary endothelial cell;cell survival;cell viability;controlled study;depression;diabetes mellitus;down regulation;electric resistance;enzyme activity;enzyme linked immunosorbent assay;female;hippocampus;immunocytochemistry;neuroapoptosis;nonhuman;protein expression;rat;signal transduction;upregulation;Western blotting

期刊：

中国神经再生研究：英文版

ISSN：

1673-5374

年：

2021

卷：

期：

页码：

727-733

DOI：

10.4103/1673-5374.296418

基金类别：

This study was supported by the National Natural Science Foundation of China, Nos. 81573965 (to YHW), 81874464 (to YHW); the Natural Science Foundation of Hunan Province of China, No. 2017JJ3241 (to JL); and the Education Department Scientific Research Foundation of Hunan Province of China, No. 17C1229 (to JL).

机构署名：

本校为其他机构

院系归属：

第一中医临床学院

摘要：

Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated with diabetes-related depression. However, the underlying mechanism remains unclear. We hypothesized that diabetes-related depression might be associated with the glutamate (Glu)/metabotropic glutamate receptor2/3 (mGluR2/3)/phosphoinositide 3-kinase (PI3K) pathway, activated by glucocorticoid ...

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Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetesrelated depression

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