Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetesrelated depression

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成果类型：

期刊论文

作者：

Wang, Yu-Hong*;Liu, Jian;Han, Yuan-Shan;Liu, Lin;Tang, Lin;...

通讯作者：

Wang, Yu-Hong

作者机构：

[Han, Yuan-Shan; Wang, Yu-Hong; Tang, Lin; Liu, Jian; Liu, Lin] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

[Zhao, Hong-Qing; Yang, Hui] Hunan Univ Chinese Med, Inst Innovat & Appl Res, Changsha, Hunan, Peoples R China.

[Meng, Pan; Zhao, Hong-Qing; Yang, Hui] Hunan Univ Chinese Med, Key Lab Chinese Mat Med Power & Innovat Drugs Est, Changsha, Hunan, Peoples R China.

[Meng, Pan; Zhao, Hong-Qing; Yang, Hui] Hunan Univ Chinese Med, Domest First Class Construct Discipline Chinese M, Changsha, Hunan, Peoples R China.

通讯机构：

[Wang, Yu-Hong] H

Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

diabetes-related depression;factor;hippocampus;in vitro;neurovascular unit;pathways;protein

期刊：

中国神经再生研究：英文版

ISSN：

1673-5374

年：

2021

卷：

期：

页码：

727-733

DOI：

10.4103/1673-5374.296418

基金类别：

the National Natural Science Foundation of China;Nos. 81573965 （to YHW）;81874464 （to YHW）； the Natural Science Foundation of Hunan Province of China;No. 2017JJ3241 （to JL）； the Education Department Scientific Research Foundation of Hunan Province of China;No. 17C1229 （to JL）；

机构署名：

本校为第一且通讯机构

院系归属：

第一中医临床学院

摘要：

Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated with diabetesrelated depression. However, the underlying mechanism remains unclear. We hypothesized that diabetes-related depression might be associated with the glutamate（Glu）/metabotropic glutamate receptor2/3(mGluR2/3)/phosphoinositide 3-kinase（PI3K） pathway, activated by glucocorticoid ...

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Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetesrelated depression

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