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Abnormal Glu/mGluR2/3/PI3K pathway in the hippocampal neurovascular unit leads to diabetesrelated depression

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成果类型:
期刊论文
作者:
Wang, Yu-Hong;Liu, Jian;Han, Yuan-Shan;Liu, Lin;Tang, Lin;...
通讯作者:
Wang, YH
作者机构:
[Han, Yuan-Shan; Wang, Yu-Hong; Tang, Lin; Liu, Jian; Liu, Lin] Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.
[Zhao, Hong-Qing; Yang, Hui] Hunan Univ Chinese Med, Inst Innovat & Appl Res, Changsha, Hunan, Peoples R China.
[Meng, Pan; Zhao, Hong-Qing; Yang, Hui] Hunan Univ Chinese Med, Key Lab Chinese Mat Med Power & Innovat Drugs Est, Changsha, Hunan, Peoples R China.
[Meng, Pan; Zhao, Hong-Qing; Yang, Hui] Hunan Univ Chinese Med, Domest First Class Construct Discipline Chinese M, Changsha, Hunan, Peoples R China.
通讯机构:
[Wang, YH ] H
Hunan Univ Chinese Med, Hosp 1, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
caspase 3;caspase 9;corticosterone;dexamethasone;excitatory amino acid transporter 1;glial cell line derived neurotrophic factor;glial fibrillary acidic protein;glucocorticoid receptor;glucose;glutamic acid;metabotropic receptor 2;metabotropic receptor 3;mitogen activated protein kinase;phosphatidylinositol 3 kinase;platelet endothelial cell adhesion molecule 1;vesicular glutamate transporter 3;animal experiment;animal model;Article;astrocyte;brain capillary endothelial cell;capillary endothelial cell;cell survival;cell viability;controlled study;depression;diabetes mellitus;down regulation;electric resistance;enzyme activity;enzyme linked immunosorbent assay;female;hippocampus;immunocytochemistry;neuroapoptosis;nonhuman;protein expression;rat;signal transduction;upregulation;Western blotting
期刊:
中国神经再生研究:英文版
ISSN:
1673-5374
年:
2021
卷:
16
期:
4
页码:
727-733
基金类别:
This study was supported by the National Natural Science Foundation of China, Nos. 81573965 (to YHW), 81874464 (to YHW); the Natural Science Foundation of Hunan Province of China, No. 2017JJ3241 (to JL); and the Education Department Scientific Research Foundation of Hunan Province of China, No. 17C1229 (to JL).
机构署名:
本校为其他机构
院系归属:
第一中医临床学院
摘要:
Our previous studies have shown that glutamate and hippocampal neuron apoptosis are key signals and direct factors associated with diabetes-related depression, and structural and functional damage to the hippocampal neurovascular unit has been associated with diabetes-related depression. However, the underlying mechanism remains unclear. We hypothesized that diabetes-related depression might be associated with the glutamate (Glu)/metabotropic glutamate receptor2/3 (mGluR2/3)/phosphoinositide 3-kinase (PI3K) pathway, activated by glucocorticoid ...

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