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Salvianolic acid A facilitates cartilage repair in knee osteoarthritis model rats by promoting WDR5 expression

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成果类型:
期刊论文
作者:
He, Hua;Dong, Dali
通讯作者:
Dong, DL
作者机构:
[He, Hua] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Nursing, Changsha 410005, Hunan, Peoples R China.
[Dong, Dali] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Orthoped, 233 Cai E North Rd, Changsha 410005, Hunan, Peoples R China.
通讯机构:
[Dong, DL ] H
Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Orthoped, 233 Cai E North Rd, Changsha 410005, Hunan, Peoples R China.
语种:
英文
关键词:
Knee osteoarthritis;Chondrogenic differentiation;Salvianolic acid A;WD repeat domain 5
期刊:
Regenerative Therapy
ISSN:
2352-3204
年:
2025
卷:
29
页码:
77-90
基金类别:
Natural Science Foundation of Changsha City [kq2208196]; Hunan University of Chinese Medicine Scientific Research Fund Project [2021XJJJ055]; Scientific Research Project of Hunan Traditional Chinese Medicine [B2024078]; Natural Science Foundation of Hunan Province [2025JJ80903, 2025JJ80920]
机构署名:
本校为第一且通讯机构
院系归属:
第二中医临床医学院
摘要:
Background The aim of this study was to investigate the regulation of Salvianolic acid A (SAA) on the chondrogenic differentiation of bone mesenchymal stem cells (BMSCs), and its effect on cartilage repair in knee osteoarthritis (KOA) model rats and the action mechanism. The aim of this study was to investigate the regulation of Salvianolic acid A (SAA) on the chondrogenic differentiation of bone mesenchymal stem cells (BMSCs), and its effect on cartilage repair in knee osteoarthritis (KOA) model rats and the action mechanism. Methods Immunohis...

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