期刊论文

Xu, Y

英文

MEDICINE

0025-7974

2023

102

43

e35503

10.1097/MD.0000000000035503

National Natural Science Foundation of China [81874466, 81904176, 82374426]; Natural Science Foundation of Hunan Province [2021JJ30531]; Scientific Research Foundation of Hunan Provincial Department of Education [21B0389]; Clinical Medical Technology Innovation Guide Project of Hunan Province [2021SK51413, 2021SK51406]; Innovation Project for Graduate Students of Hunan University of Chinese Medicine [2023CX07]

本校为第一机构

Cuproptosis has been reported to affect a variety of diseases. Therefore, we aimed to examine the role of cuproptosis-related genes in active ulcerative colitis (UC). We acquired 2 datasets of active UC from the Gene Expression Omnibus database and created immune cell infiltrations to research immune cell dysregulation. Based on the cuproptosis gene set and differentially expressed genes (DEGs), we identified the differentially expressed genes of cuproptosis (CuDEGs). We then used 2 machine learning methods to screen hub CuDEGs. Subsequently, we performed validation on additional datasets and ...