GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics

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成果类型：

期刊论文

作者：

Zhang, Chanjuan;Qin, Yan;Deng, Changfeng;Zhu, Neng;Shi, Yaning;...

作者机构：

[Deng, Changfeng; Shi, Yaning; Zhang, Chanjuan; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Lab Stem Cell Regulat Chinese Med & Its Applicat, Changsha 410208, Peoples R China.

[Qin, Yan; Wang, Wei; Zhang, Chanjuan] Hunan Univ Chinese Med, Sch Pharm, TCM & Ethnomedicine Innovat & Dev Int Lab, Changsha 410208, Peoples R China.

[Zhu, Neng] First Hosp Hunan Univ Chinese Med, Dept Urol, Changsha 410007, Peoples R China.

[Qin, Li] Hunan Univ Chinese Med, Inst Key Lab Vasc Biol & Translat Med Hunan Prov, Changsha 410208, Peoples R China.

[Qin, Li] Hunan Univ Chinese Med, Hunan Engn Technol Res Ctr Bioact Subst Discovery, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Glutathione;Fluorescence probe;Celastrol;Clear cell renal cell carcinoma

期刊：

Analytica Chimica Acta

ISSN：

0003-2670

年：

2023

卷：

1248

页码：

340933

DOI：

10.1016/j.aca.2023.340933

基金类别：

National Natural Sciences Foundation of China [82274159, 81973668, 81774130, 82003931]; National Science Foundation of Hunan Province [2022JJ80088, 2020JJ5421]; Key Project of the Educational Department of Hunan Province [20A375]; Outstanding Youth Foundation of Hunan Provincial Education Department [20B445]; Scientific Research Project of Changsha Science and Technology Bureau [kq2004060]; Key Project of Hunan Provincial Health Commission [202213055529]; Ministry of Traditional Chinese Medicine Powder and Innovative Drug Research in Hunan Province; First -Class Discipline of Pharmaceutical Science of Hunan; [21PTKF1004]

机构署名：

本校为第一机构

院系归属：

药学院

摘要：

High level of intracellular glutathione (GSH) has been identified as a major barrier for cancer therapy. Therefore, effective regulation of GSH can be regarded as a novel approach for cancer therapy. In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent n...

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GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics

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