The lipid rafts in cancer stem cell: a target to eradicate cancer

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成果类型：

期刊论文

作者：

Zhang, Shuo;Zhu, Neng;Li, Hong Fang;Gu, Jia;Zhang, Chan Juan;...

通讯作者：

Qin, Li

作者机构：

[Zhang, Shuo; Zhang, Chan Juan; Li, Hong Fang; Liao, Duan Fang; Gu, Jia; Qin, Li] Hunan Univ Chinese Med, Sch Pharm, Lab Stem Cell Regulat Chinese Med & Its Applicat, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Zhu, Neng] Hunan Univ Chinese Med, Dept Urol, Hosp 1, Changsha, Peoples R China.

[Qin, Li] Hunan Univ Chinese Med, Inst Key Lab Vasc Biol & Translat Med Hunan Prov, Changsha, Peoples R China.

[Qin, Li] Hunan Univ Chinese Med, Hunan Prov Engn Res Ctr Bioact Subst Discovery Tr, Changsha, Peoples R China.

通讯机构：

[Qin, Li] L

Laboratory of Stem Cell Regulation With Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, 300 Xueshi Road, Hanpu Science and Education District, 410208, Changsha, Hunan, People's Republic of China.

Institutional Key Laboratory of Vascular Biology and Translational Medicine in Hunan Province, Hunan University of Chinese Medicine, Changsha, China.

Hunan Province Engineering Research Center of Bioactive Substance Discovery of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.

语种：

英文

关键词：

Lipid raft;Cancer;Cancer stem cell;Self-renewal;Drug resistance;Epithelial-mesenchymal transition;Cancer stem cell niche

期刊：

Stem Cell Research & Therapy

ISSN：

1757-6512

年：

2022

卷：

期：

页码：

1-15

DOI：

10.1186/s13287-022-03111-8

基金类别：

National Natural Sciences Foundation of China [81973668, 81774130]; Key Project of the Educational Department of Hunan Province [20A375]; Pharmaceutical Open Fund of Domestic First-class Disciplines (cultivation) of Hunan Province [2021YX07]; Scientific Research Project of Changsha Science and Technology Bureau [kq2004060]; Key Project of Hunan Provincial Health Commission [Number202213055529]; Natural Science Foundation of Hunan Province [2022JJ80088]; Graduate Research innovation project of Hunan University of Chinese Medicine [2021CX48, 2021CX08]; First-Class Discipline of Pharmaceutical Science of Hunan

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

药学院

摘要：

Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in the plasma membrane that mediate various intracellular signaling. The occurrence and progression of cancer are closely related to lipid rafts. Emerging evidence indicates that lipid raft levels are significantly enriched in CSCs compared to cancer cells and that most CSC markers such as CD24, CD44, and CD133 are located in lipid rafts. Furthermore, lipid r...

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The lipid rafts in cancer stem cell: a target to eradicate cancer

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