期刊论文

Prevention of Eperidurai Fibrosis and Adhesion after Laminectomy with Tetramethyipyrazine and Autogenous Periosteum Graft

中文

中国康复理论与实践

1006-9771

2010

16

1

32-34+101

10.3969/j.issn.1006-9771.2010.01.014

湖南省自然科学基金资助课题（07JJ6048）；

本校为第一机构

目的 观察椎板切除术后用川芎嗪并在椎板缺损处植入自体骨膜预防硬膜外粘连的效果.方法 48只SD大鼠随机分成A、B、C、D 4组,制作L2板损伤模型.A组硬膜外涂布生理盐水,B组硬膜外涂布川芎嗪,C组硬膜外覆盖自体骨膜,D组硬膜外涂布川芎嗪的同时加自体骨膜覆盖.术后12周对椎板切除部位进行大体观察、组织学观察、生化检查比较组间瘢痕形成和粘连情况.结果 B、C、D组的改良Rydell-Balazs粘连韧度评分、胶原含量、改良Nussvuaum组织学评分均明显优于A组(P

Objective To study the effect of tetramethylpyrazine cooperated with autogenous periosteum graft on fibrous scar formation in the epidural space after laminectomy. Methods 48 SD rats were divided randomly into 4 groups. Laminectomy was performed in lumbar 2 segment, and the exposed duras were covered with saline solution （group A）, tetramethylpyrazine （group B）, autogenous periosteum （group C）, and tetramethylpyrazine and autogenous periosteum （group D） respectively. 12 weeks postoperatively, they were evaluated with the gross and histo...