Acid-Sensing Ion Channel 1/Calpain1 Activation Impedes Macrophage ATP-Binding Cassette Protein A1-Mediated Cholesterol Efflux Induced by Extracellular Acidification

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成果类型：

期刊论文

作者：

Wang, Yuan-Mei;Tan, Mo-Ye;Zhang, Rong-Jie;Qiu, Ming-Yue;Fu, You-Sheng;...

通讯作者：

Gu, Hong-Feng;Xie, Xue-Jiao

作者机构：

[Gu, Hong-Feng; Wang, Yuan-Mei; Qiu, Ming-Yue; Zhang, Rong-Jie] Univ South China, Hengyang Key Lab Neurodegenerat & Cognit Impairme, Hengyang, Peoples R China.

[Gu, Hong-Feng; Wang, Yuan-Mei; Qiu, Ming-Yue; Zhang, Rong-Jie] Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang, Peoples R China.

[Tan, Mo-Ye; Xie, Xue-Jiao] Hunan Univ Chinese Med, Coll Chinese Med, Dept Zhongjing Theory, Changsha, Peoples R China.

[Fu, You-Sheng] Hengyang Hosp Tradit Chinese Med, Hengyang, Peoples R China.

通讯机构：

[Gu, Hong-Feng] U

[Xie, Xue-Jiao] H

Univ South China, Hengyang Key Lab Neurodegenerat & Cognit Impairme, Hengyang, Peoples R China.

Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang, Peoples R China.

Hunan Univ Chinese Med, Coll Chinese Med, Dept Zhongjing Theory, Changsha, Peoples R China.

语种：

英文

关键词：

Extracellular acidification;Foam Cells;ASIC1;Calpain1;ABCA1;Cholesterol efflux

期刊：

Frontiers in Physiology

ISSN：

1664-042X

年：

2022

卷：

页码：

777386

DOI：

10.3389/fphys.2021.777386

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (Grant No. 81500349), the Natural Science Foundation of Hunan Province, China (Grant Nos. 2020JJ4528 and 2021JJ30510), the key program of the Educational Commission of Hunan Province, China (Grant No. 19A435), program of the Educational Commission of Hunan Province, China (Grant No. 19K069), and the Health and Family Planning Commission of Hunan Province, China (Grant No. B2017048).

机构署名：

本校为通讯机构

摘要：

Background: Extracellular acidification is a common feature of atherosclerotic lesions, and such an acidic microenvironment impedes ATP-binding cassette transporter A1 (ABCA1)-mediated cholesterol efflux and promotes atherogenesis. However, the underlying mechanism is still unclear. Acid-sensing ion channel 1 (ASIC1) is a critical H+ receptor, which is responsible for the perception and transduction of extracellular acidification signals. Aim: In this study, we explored whether or how ASIC1 influences extracellular acidification-induced ABCA1-m...

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Acid-Sensing Ion Channel 1/Calpain1 Activation Impedes Macrophage ATP-Binding Cassette Protein A1-Mediated Cholesterol Efflux Induced by Extracellular Acidification

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