Objective: To confirm evidence regarding the potential therapeutic effect of Hericium erinaceus (H. erinaceus, Hou Tou Gu, 猴头菇) on Alzheimer's disease (AD) using a system pharmacological approach in silico. Methods: The active compounds of H. erinaceus were screened from the TCMDatabase@Taiwan, PubMed, and Pubchem. The predicted targets of H. erinaceus were selected by using the Similarity Ensemble Approach Database and the DisGeNET database was used to screen the targets related to AD. The compound-target-AD network was built. GO analysis a...